Publications

23. U. I. M. Gerling-Driessen, M. Hoffmann, S. Schmidt, N. L. Snyder, L. Hartmann "Glycopolymers against pathogen infection", Chem. Soc. Rev., 2023, 52, 2617-2642, Journal Cover

22. M. D. Driessen§, H. L. Junghans§, L. Hartmann, U. I. M. Gerling-Driessen* "Multi-Tag: A modular platform of bioorthogonal probes for multi-modal (glyco)protein analysis" bioRxiv, 2022, § Contributed equally

21. S. Walber, G. Partalidou, U. I. M. Gerling-Driessen* "NGLY1 Deficiency: A Rare Genetic Disorder Unlocks Therapeutic Potential for Common Diseases" Isr. J. Chem., 2022

20. P. B. Konietzny, H. Peters, M. L. Hofer, U. I. M. Gerling-Driessen, R. P. de Vries, T. Peters, L. Hartmann, "Enzymatic Sialylation of Synthetic Multivalent Scaffolds: From 3′-Sialyllactose Glycomacromolecules to Novel Neoglycosides" Macromol. Biosci., 2022

19. M. Santos de Freitasa, R. Rezaei Araghi, E. Brandenburg, J. Leitererd, F. Emmerling, K. Folmert, U. I. M. Gerling-Driessen, B. Bardiaux, C. Böttcher, K. Pagel, A. Diehl, H. v. Berlepsch, H. Oschkinat, B. Koksch, “The protoﬁlament architecture of a de novo designed coiled coil-based amyloidogenic peptide” J. Struct. Biol., 2018, 203, 263–272.

18. F. M. Tomlin§, U. I. M. Gerling-Driessen§, Y-C. Liu, R. A. Flynn, J. R. Vangala, C. S. Lentz, S Clauder-Muenster, P. Jakob, W. F. Mueller, D. Ordonez, M. Paulsen, N. Matsui, D. Foley, A. Rafalko, T. Suzuki, M. Bogyo, L. M. Steinmetz, S. K. Radhakrishnan, C. R. Bertozzi; “Inhibition of NGLY1 inactivates the transcription factor Nrf1 and potentiates proteasome inhibitor cytotoxicity” ACS Cent. Sci. 2017, 3, 1143-1155. § Contributed equally

17. J. D. Castillo Gomez, A. Hagenbach, U. I. M. Gerling-Driessen, B. Koksch, N. Beindorff, W. Brenner, U. Abram; “Thiourea derivatives as chelating agents for bioconjugation of rhenium and technetium” Dalton Trans. 2017, 46, 14602-14611.

16. J-S. Völler, M. Dulic, U. I. M. Gerling-Driessen, H. Biava, T. Baumann, N. Budisa, I. Gruic-Sovulj, B. Koksch; “Discovery and Investigation of Natural Editing Function against Artificial Amino Acids in Protein Translation” ACS Cent. Sci. 2017, 3, 73-80.

15. U. I. M. Gerling-Driessen, N. Mujkic-Ninnemann, D. Ponader, D. Schöne, L. Hartmann, B. Koksch; “Exploiting Oligo(amido amine) Backbones for the Multivalent Presentation of Coiled-Coil Peptides” Biomacromolecules, 2015, 16, 2394-2402.

14. S. Huhmann, E. K. Nyakatura, H. Erdbrink, U. I. M. Gerling, C. Czekelius, B. Koksch; “Effects of single substitutions with hexafluoroleucine and trifluorovaline on the hydrophobic core formation of a heterodimeric coiled coil” J. Fluor. Chem. 2015, 175, 32-35.

13. U. I. M. Gerling§, M.S. Miettinen§, B. Koksch; “Concluding the amyloid formation pathway from the size of the critical nucleus” ChemPhysChem 2015, 16, 108-114. § Contributed equally

12. U. I. M. Gerling, M. Salwiczek, C. D. Cadicamo, H. Erdbrink, C. Czekelius, S. L. Grage, P. Wadhwani, A. S. Ulrich, M. Behrends, G. Haufe, B. Koksch; “Fluorinated amino acids in amyloid formation: a symphony of size, hydrophobicity, and α-helix propensity” Chem. Sci. 2014, 5, 819-830.

11. J. Maity§, U. I. M. Gerling§, S. Vukelić, A. Schäfer, B. Koksch; “Proline-glutamate chimera’s side chain conformation directs the type of β-hairpin structure” Amino Acids, 2014, 46, 177-186. § Contributed equally

10. H. Erdbrink, E. K. Nyakatura, S. Huhmann, U. I. M. Gerling, D. Lentz, B. Koksch; “Synthesis of enantiomerically pure (2S,3S)-5,5,5-trifluoroisoleucine and (2R,3S)-5,5,5-trifluoro-allo-isoleucine” Beilstein J. Org. Chem. 2013, 9, 2009-2014.

9. P. D. Rakowska, H. Jiang, S. Ray, A. Pyne, B. Lamarre, M. Carr, P. J. Judge, J. Ravi, U. I. M. Gerling, B. Koksch, G. J. Martyna, B. W. Hoogenboom, A. Watts, J. Crain, C. R. M. Grovenor, M. G. Ryadnov; “Nanoscale imaging reveals laterally expanding antimicrobial pores in lipid bilayers” Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 8918-8923.

8. H. Erdbrink, I. Peuser, U. I. M. Gerling, D. Lentz, B. Koksch, C. Czekelius; “Conjugate hydrotriﬂuoromethylation of α, β-unsaturated acyl-oxazolidinones: synthesis of chiral ﬂuorinated amino acids” Org. Biomol. Chem. 2012, 10, 8583-8586.

7. M. Salwiczek, E. K. Nyakatura, U. I. M. Gerling, S. Ye, B. Koksch; “Fluorinated Amino Acids: Compatibility with native protein structures and effects on protein-protein interactions” Chem. Soc Rev. 2012, 41, 2135-2171. * Journal cover

6. J. Maity, P. Saha, U. I. M. Gerling, D. Lentz, B. Koksch; “An approach for simultaneous synthesis of cis- and trans-3-substituted proline-glutamic acid chimeras” Synthesis, 2012, 44, 3063-3070.

5. R. Rezaei Araghi, C. Baldauf, U. I. M. Gerling, C. D. Cadicamo, B. Koksch; “A systematic study of fundamentals in a-helical coiled coil mimicry by alternating sequences of β- und γ-amino acids” Amino Acids, 2011, 41, 733-742.

4. E. Brandenburg, H. v. Berlepsch, U. I. M. Gerling, C. Böttcher, B. Koksch; “Inhibition of Amyloid Aggregation by Formation of Helical Assemblies” Chem. Eur. J. 2011, 17, 10651-10661.

3. U. I. M. Gerling, E. Brandenburg, H.v. Berlepsch, K. Pagel, B. Koksch; “Structure Analysis of an Amyloid-Forming Model Peptide by a Systematic Glycine and Proline Scan” Biomacromolecules, 2011, 12, 2988-96.

2. A. Botev, L.M. Munter, R. Wenzel, L. Richter, V. Althoff, J. Ismer, U. Gerling, C. Weise, B. Koksch, P.W. Hildebrand, R. Bittl, G. Multhaup; “The Amyloid Precursor Protein C-Terminal Fragment C100 Occurs in Monomeric and Dimeric Stable Conformations and Binds γ-Secretase Modulators” Biochemistry, 2011, 50, 828-825.

1. J.A. Falenski, U. Gerling, B. Koksch; “Multiple glycosylation of de novo designed alpha-helical coiled coil peptides” Bioorg. Med. Chem. 2010, 18, 3703-3706.